Effect of Alkylamine Based Ion-pairing Reagents in Analysis of siRNA

Abstract:

If the separation of sense and anti-sense strand when characterizing double-stranded oligonucleotides is prioritized, TEA will likely yield more favorable chromatography and more reproducible results. As such, other factors impacting MS performance, including modulation of HFIP concentration, might need to be implemented.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

bioZen

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