Separation of Common Sugar Alcohols Used as Excipients with A Novel HILIC Selectivity

Abstract:

For the purpose of this technical note, we demonstrated the separation of sugar alcohols commonly utilized as excipients in pharmaceutical formulations. We prioritized the achievement of chromatographic resolution between sugar alcohols because of the strong chemical similarities, especially in the case of sorbitol and mannitol. Sorbitol and mannitol are positional isomers that dif-fer by the orientation of a hydroxyl group on the 2-carbon. We first achieved chromatographic resolution of a 5-sugar alcohol standard that contained erythritol, xylitol, sorbitol, mannitol, and maltitol. Af-ter, we applied the same chromatographic mode of separation to a melatonin base sleeping aid that contained the excipients xylitol and mannitol.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Luna

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