Stationary Phases for the Process Scale Purification of Peptides and Insulin Analogs

Abstract:

The development of a multi-step purification process on two types of silicas is presented here for commercially significant crude insulin analog, Insulin Glargine. The focus of this tech note is to demonstrate the efficacy of both prep C8 phases on a well-established USP method that has been further optimized on the analytical format and then scaled to the prep format to produce material of a suitable purity. The investigative parameters include base silica and gradient conditions.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Luna Kinetex Gemini

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